Home » Gentamicin Sinus Irrigation

Gentamicin sinus irrigation is another treatment for sinusitis.  This is an antibiotic mixed with normal saline, either used alone or added in to your regular saline sinus rinse. This solution is considered to be a compounded medicine. Therefore, it is mixed only when ordered and made by a specialty or compounding pharmacy.  Allow at least 24-48 hours for your prescription to be ready.  Follow the instructions the pharmacy gives you for storing the medicine and expiration dates.

What will I need to buy?

  • Neil Med Sinus Rinse Kit (available for purchase from our office, pharmacy, or retail store such as Target and Wal-mart.
  • Distilled water

How to Irrigate

  • Clean your irrigating device before and after every use. To disinfect the bottle, you can put the bottle in the microwave for 30-45 seconds, wash it with warm, soapy water and let it air dry or follow the cleaning instructions that came with your device.
  • Make your saline sinus rinse as usual, but fill the bottle with distilled water to about one inch below the fill line to allow room for the gentamicin solution.
  • Measure out the amount of the gentamicin solution you will need. The usual dose is 50 mL.  You may let the solution you measured out warm up for 30 minutes before you use it. Keep the rest of the solution in the refrigerator.
  • Add the gentamicin solution to your normal saline sinus rinse and irrigate the right nostril with half of the bottle, then the left with the remaining amount.
  • Lean over the sink or stand in the shower.  Place the tip of the bottle up to your nostril. Aim for the back of your head, not the top of your head. Gently squeeze the bottle to  help the solution move through your sinuses and out your other nostril. Repeat these steps with your other nostril, using the other 1/2 of the solution.
  • Rinse both nostrils with the gentamicin solution 2 times a day for 4 weeks.

You may feel mild burning or stinging when you rinse with the solution. This should go away after the first few times you use it.  If you experience any unusual side effects, please contact the office.

Click on the following link for a PDF version:  Gentamicin Sinus Rinse Instructions




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